Supporters of Biozipcode
Supporters of Biozipcode
Supporters of Biozipcode [Crowdfunding Initiative]2025-03-07T12:24:07+09:00

Goodbye to Diabetes.

Goodbye to Diabetes.

Goodbye to Diabetes.

Support research for a complete cure for diabetes and its complications.
To bring this groundbreaking treatment to the world, funding for clinical trials is essential.

Support research for a complete cure for diabetes and its complications. To bring this groundbreaking treatment to the world, funding for clinical trials is essential.

Support the Crowdfunding Campaign

Current treatments only manage symptoms.

Current treatments only manage symptoms.

Even specialists do not claim that diabetes can be cured.
It is widely recognized that once diabetes develops, it cannot be cured.

Even specialists do not claim that diabetes can be cured. It is widely recognized that once diabetes develops, it cannot be cured.

A Silent Threat

Early symptoms include excessive thirst, frequent urination, and fatigue, but many people do not realize they have the disease.

Only Symptom Management

Diabetes treatment focuses on blood sugar control, but no cure has been developed yet.

The Severity of Diabetes

Fluctuating blood sugar levels affect the heart, kidneys, vision, and other organs, leading to severe complications if left untreated.

A Silent Threat

Early symptoms include excessive thirst, frequent urination, and fatigue, but many people do not realize they have the disease.

Only Symptom Management

Diabetes treatment focuses on blood sugar control, but no cure has been developed yet.

The Severity of Diabetes

Fluctuating blood sugar levels affect the heart, kidneys, vision, and other organs, leading to severe complications if left untreated.

A Future Where ‘Diabetes is Incurable’ Becomes History

A revolutionary drug that can completely cure diabetes and its complications without any side effects is nearing completion.

Support Biozipcode, Inc. to Achieve Two Major Goals

  • Developing a complete cure for diabetes
  • Creating side-effect-free drugs using Biozipcode (biological postal code) technology

A Future Where ‘Diabetes is Incurable’ Becomes History

A revolutionary drug that can completely cure diabetes and its complications without any side effects is nearing completion.

Support Biozipcode, Inc. to Achieve Two Major Goals

  • Developing a complete cure for diabetes
  • Creating side-effect-free drugs using Biozipcode (biological postal code) technology

Complete Cure for Diabetes

A joint research study by Biozipcode, Inc. and Shiga University of Medical Science has confirmed* complete remission of diabetes in mice.

*Kojima, H. Commun Biol 6, 637 (2023).

Curing Complications as Well

This treatment is also effective* against diabetic complications, making the complete cure of nephropathy, retinopathy, and neuropathy possible. It can address the root causes of many currently untreatable diseases.

*Katagi, M. Commun Biol 4, 575 (2021).

Repurposing Existing Drugs

HDAC inhibitors* are already commercially available and can be applied for diabetes treatment. Their safety has already been established.

*KIYAN MEDICAL Co., Ltd. – Developing a complete cure for diabetes

Clinical Trials Worldwide

Clinical Trials

We plan to conduct physician-led clinical trials in Japan, Palau, and the United States to secure insurance coverage as soon as possible.

  • Complete remission of STZ diabetes by removing “Diabetes Stem Cells”

Ongoing Development for Regulatory Approval

Join the Supporters of Biozipcode

The Supporters of Biozipcode is actively collaborating with Biozipcode, Inc. to accelerate the development and clinical trials of a complete cure for diabetes. Our goal is to obtain regulatory approval for insurance-covered medication as soon as possible.

  • About the Supporters of Biozipcode: An organization within Studio Makyu Co., Ltd., led by Fumihisa Kojima, son of the treatment’s developer, Professor Hideto Kojima.

Development of a Diagnostic Test for Diabetes

Until now, diabetes diagnosis has relied on blood sugar measurements, but there was no definitive test. The discovery of diabetes stem cells now allows for a companion diagnostic test that detects their presence in peripheral blood.

Development of a Cure for Diabetes

Researchers discovered that abnormal hematopoietic stem cells (‘diabetes stem cells’) prevent pancreatic islet regeneration, making diabetes difficult to treat. By combining insulin and an HDAC inhibitor, these diabetes stem cells were eliminated, leading to complete remission in mice.

A Completely Side-Effect-Free Drug

We are developing a revolutionary system that delivers drugs only to specific cells. Using a seven-digit amino acid sequence inspired by the Japanese postal code system, we can precisely target cells, minimizing side effects and maximizing efficacy.

From Clinical Trials to Insurance-Covered Treatment

The journey from initial discovery to clinical trials and regulatory approval involves multiple stages. Our goal is to ensure this treatment is not just available as an expensive private therapy but as an insurance-covered drug accessible worldwide.

*Since the compounds used have already been approved for other indications, we are now working towards conducting physician-led clinical trials in humans.

*How Support Funds Will Be Used: A portion of the funds raised will be allocated to Biozipcode, Inc.’s cell-targeting technology research to develop side-effect-free drugs, including a complete cure for diabetes.

Development of a Diagnostic Test for Diabetes

Until now, diabetes diagnosis has relied on blood sugar measurements, but there was no definitive test. The discovery of diabetes stem cells now allows for a companion diagnostic test that detects their presence in peripheral blood.

Development of a Cure for Diabetes

Researchers discovered that abnormal hematopoietic stem cells (‘diabetes stem cells’) prevent pancreatic islet regeneration, making diabetes difficult to treat. By combining insulin and an HDAC inhibitor, these diabetes stem cells were eliminated, leading to complete remission in mice.

A Completely Side-Effect-Free Drug

We are developing a revolutionary system that delivers drugs only to specific cells. Using a seven-digit amino acid sequence inspired by the Japanese postal code system, we can precisely target cells, minimizing side effects and maximizing efficacy.

From Clinical Trials to Insurance-Covered Treatment

The journey from initial discovery to clinical trials and regulatory approval involves multiple stages. Our goal is to ensure this treatment is not just available as an expensive private therapy but as an insurance-covered drug accessible worldwide.

  • Since the compounds used have already been approved for other indications, we are now working towards conducting physician-led clinical trials in humans.
  • How Support Funds Will Be Used: A portion of the funds raised will be allocated to Biozipcode, Inc.’s cell-targeting technology research to develop side-effect-free drugs, including a complete cure for diabetes.
Support the Crowdfunding Campaign

A complete cure for diabetes is within reach.

We sincerely ask for your financial support for diabetes cure research and development. Several crowdfunding support plans are available.

  • You can contribute as many units as you wish, and we sincerely appreciate the support of those who align with the mission of the Supporters of Biozipcode.

  • This crowdfunding initiative primarily follows a donation-based model. While there are no direct returns in the form of products or services, we will provide regular project updates and heartfelt acknowledgments to our supporters. For more details, please refer to the FAQ section.

  • For those who choose the 5-ALA Plan, contributors who support at least one unit will receive one box (50 mg, 60 capsules) of 5-ALA supplements from our sponsor, KIYAN PHARMA Co., Ltd., for each unit contributed. (Note: Consumption tax applies.)

  • For the 5-ALA plan, an additional ¥5,000 JPY will be required for international shipping.

We seek your support to help people around the world.

We have prepared two support plans for you to choose from.

Support Plan: ¥10,000 JPY (About $65 USD) per unit

Support Plan:
¥10,000 JPY (About $65 USD) per unit

  • Contributions start from ¥1 JPY 

  • Access to the community group

  • Thank-you email from the development team

  • Regular updates on the project’s progress

  • Personalized supporter messages can be featured on the portal site
    (For contributions of 100 units or more, corporate logos and sponsorship announcements are available)

5-ALA Plan: ¥11,000 JPY (About $70 USD) per unit

5-ALA Plan:
¥11,000 JPY (About $70 USD) per unit

  • Minimum contribution: 1 unit

  • Access to the community group

  • Thank-you email from the development team

  • Regular updates on the project’s progress

  • Receive one box of 5-ALA supplements (50 mg, 60 capsules) per unit

  • Consumption tax applies (10%)

Project Team

The Supporters of Biozipcode is committed to supporting drug and treatment approval.

Our team includes doctors, pharmacists, researchers, engineers, influencers, and volunteers dedicated to eradicating diabetes and its complications worldwide. This initiative extends beyond Japan, aiming to eliminate diabetes globally, including in the United States.

KIYAN MEDICAL Co., Ltd.
KIYAN PHARMA Co., Ltd.
Studio Makyu Co., Ltd.

Frequently Asked Questions (FAQ)

Here are answers to common questions about the crowdfunding campaign for diabetes cure research and development.

If you have any questions that are not covered in this FAQ, please feel free to contact us through the inquiry form.

About the Supporters of Biozipcode

What Is the Main Purpose of the Supporters of Biozipcode?2025-03-03T18:53:35+09:00

The primary goal of the Supporters of Biozipcode is to support the development of treatments for diabetes and its complications and to help bring the results of ongoing research to the world. Our ultimate mission is to improve the quality of life for diabetes patients worldwide.

Biozipcode, Inc. is focused on researching and developing new diagnostic methods and treatments that target abnormal hematopoietic stem cells, which are considered a key reason why diabetes is difficult to cure. By addressing this root cause, we aim to provide more effective treatments that lead to complete remission rather than just managing the disease. Furthermore, by enabling a true cure, we seek to reduce the medical and economic burden of diabetes treatments, including dialysis and other costly interventions.

Additionally, the development of side-effect-free drugs will be made possible through Biozipcode technology. The Biozipcode (biological postal code), or BIOZIPCODE, is a seven-amino-acid peptide that functions like a biological version of Japan’s postal code system. It binds specifically to targeted organs and cells, allowing precise delivery of therapeutic agents. This technology is set to revolutionize both molecular-level diagnostics and targeted treatments.

The Supporters of Biozipcode is committed to supporting Biozipcode, Inc. in every possible way to achieve two major objectives:

  • Developing a complete cure for diabetes
  • Creating side-effect-free drugs using Biozipcode technology
What Scientific Evidence Supports the Development of a Cure for Diabetes?2025-03-03T18:57:52+09:00

The development of a cure for diabetes is based on critical scientific discoveries.

Recent studies have revealed the role of bone marrow-derived cells (BMDCs) in the progression of diabetes. In particular, a subset of BMDCs known as Vcam1-positive short-term hematopoietic stem cells (Vcam1+ ST-HSCs) has been identified as a major contributor to the development of diabetic complications. It is hypothesized that these cells continuously damage pancreatic β-cells, which are essential for insulin production.

Based on this discovery, a treatment combining insulin therapy with the removal of abnormal BMDCs was tested in diabetic mouse models. Researchers found that bone marrow transplantation successfully eliminated abnormal BMDCs, allowing the mice to maintain normal blood sugar levels even after discontinuing insulin therapy. Furthermore, an alternative approach using the HDAC inhibitor givinostat was also found to be effective. Givinostat corrected epigenetic abnormalities in BMDCs, and after treatment discontinuation, both insulin secretion and blood glucose normalization were sustained.

Additionally, this combination therapy was shown to suppress abnormal BMDC migration to the pancreatic islets and thymus, as well as cell fusion events caused by diabetes. However, in diabetic mice that underwent thymectomy (surgical removal of the thymus), the treatment was ineffective. This finding suggests that diabetes is not only a bone marrow disorder but also involves epigenetic dysfunction in the thymus.

These research findings have direct implications for the development of a diabetes cure. The combination therapy of insulin and givinostat has the potential for clinical application as a groundbreaking treatment that aims for complete remission (cure) of diabetes.

For more details, please refer to the Nature Communication Biology research paper.

Can I Donate Directly to Biozipcode, Inc.?2025-03-03T19:02:00+09:00

Yes, direct donations to Biozipcode, Inc. are possible.

The Supporters of Biozipcode initiative, operated by Studio Makyu Co., Ltd., is dedicated to fundraising and business collaboration to support research and development at Biozipcode, Inc..

If you wish to make a direct donation, please contact Biozipcode, Inc. directly or reach out via this inquiry form.

Who Are the Key Collaborators and Partners in This Initiative?2025-03-03T19:03:47+09:00

The Supporters of Biozipcode initiative collaborates closely with two key partners: Biozipcode, Inc. and the Shiga University of Medical Science, Department of Regenerative Medicine.

Biozipcode, Inc. was established to apply and commercialize the research findings developed at the Shiga University of Medical Science, Department of Regenerative Medicine. The company is dedicated to pioneering new approaches to diabetes treatment and side-effect-free therapies, using cell-targeting technology.

Meanwhile, the Shiga University of Medical Science, Department of Regenerative Medicine plays a crucial role as an advanced medical research institution, driving deeper exploration into this field.

Both institutions collaborate by sharing scientific expertise and resources to advance the development of innovative treatments for diabetes.

Who Operates the Supporters of Biozipcode?2025-03-03T19:05:28+09:00

The Supporters of Biozipcode is an independent initiative operated within Studio Makyu Co., Ltd..

The initiative is primarily led and managed by Fumihisa Kojima, the CEO of Studio Makyu Co., Ltd., who oversees its operations and activities.

About the Crowdfunding Campaign

What is the total amount required for research and development?2025-03-03T18:39:53+09:00

The development of a cure for diabetes and its complications is estimated to require at least ¥300 million (approximately $2 million) over the next three years to maintain the current research infrastructure. Additionally, for next-generation, side-effect-free cell-targeting technology-based drugs, the basic technology development alone is expected to cost around ¥2 billion (approximately $13 million). This includes expenses for experimental materials, equipment, personnel, and clinical trials.

The total cost of developing a new drug for human use, including clinical trials, typically ranges from tens of billions to over ¥100 billion (hundreds of millions of dollars). To secure the necessary funding for research, clinical trials, and regulatory approval, Biozipcode, Inc. is exploring multiple avenues, including investment from investors, government and private grants, and joint research through strategic partnerships. Efficient fundraising and resource optimization are essential for the success of new drug development.

Studio Makyu Co., Ltd. is actively working to build a strong support system for developing a complete cure for diabetes. In addition to crowdfunding, we are pursuing various funding strategies and resource optimization approaches from multiple perspectives to accelerate this mission.

How Will the Funds Be Used?2025-03-07T10:16:35+09:00

The funds raised through “Supporters of Biozipcode” (operated by Studio Makyu Co., Ltd.) will primarily be allocated to Biozipcode, Inc., which is engaged in joint projects and collaborative research. The funds will be used for purchasing experimental materials, upgrading research equipment, covering researchers’ salaries, and conducting clinical trials.

Additionally, the funds may also be used for data analysis, publication of research findings, and related patent applications. A full breakdown of all donations will be publicly disclosed.

Are Donations Tax-Deductible?2025-03-03T18:46:14+09:00

For donations made in Japan, please refer to the National Tax Agency’s website for information on tax implications. Since this is a donation-based crowdfunding, there are no specific services or products provided in return, meaning donations are not subject to consumption tax. However, for the 5-ALA Plan, a product is included, so consumption tax will apply. Please keep this in mind when making a contribution.

For corporate sponsors interested in supporting this project or forming business partnerships, please contact us. Additionally, donations made directly to a university research lab may qualify as deductible expenses under certain systems.

For donations made outside Japan, please check the tax regulations specific to your country.

How Will Research and Development Progress Be Reported?2025-03-03T18:46:55+09:00

The progress of research and development will be regularly disclosed through updates on this website, social media, and press releases. Additionally, when significant milestones are achieved, special reports will be provided to supporters.

For those who register their email address, we will also send regular updates on development progress.

Why Are We Not Using Major Crowdfunding Platforms?2025-03-07T02:03:52+09:00

The main reason is the high fees associated with major crowdfunding platforms. A quick search will show the fee structures of various platforms, but when including payment processing fees, the total commission can amount to approximately 17% to 20%.

*In the future, we may consider using major crowdfunding platforms.

Project Updates and Acknowledgments

Thank-You Email from the Development Team2025-03-03T18:49:14+09:00

As a token of our appreciation, the Supporters of Biozipcode team will send a thank-you email to those who contribute to our crowdfunding campaign.

Your support is invaluable in helping us advance the development of a complete cure for diabetes and its complications. Through this email, we wish to express our deepest gratitude for your generosity and belief in our mission.

We will continue to provide regular updates on the project’s progress, ensuring you stay informed about how your support is making a difference.

Name Listing on Our Website as a Supporter (Optional, Nicknames Allowed)2025-03-03T18:54:02+09:00

If you wish, we can include your name or nickname on our project page as a supporter. This is entirely optional, and you may also choose not to be listed.

This acknowledgment serves as a token of our gratitude for your support and allows us to permanently recognize your contribution within our community.

Displaying Supporter Messages on Our Website2025-03-03T18:51:29+09:00

We would love to feature your thoughts and messages of support on a special section of our website. Your words of encouragement will be a great source of motivation not only for our team but also for everyone who visits our site.

Along with your message, we will also list your name as a supporter (optional, nicknames allowed). You may also choose not to have your name displayed.

You can access the “Supporters” page, featuring individuals, organizations, and companies who support our project, here.

Regular Updates on Development Progress2025-03-03T18:52:35+09:00

We will provide regular updates on the latest progress of the project through emails and a dedicated webpage. Additionally, we will share updates via various social media platforms to keep supporters informed.

By sharing our development process in real-time, we invite you to be a part of our journey and witness our progress firsthand.

News

Spread the Word / Share on Social Media

Helping us raise awareness of this research is a powerful form of support.

Even simply sharing this project on social media helps bring attention to our mission. If you’re unable to contribute financially, you can still support us by spreading the word online.

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  • Please like and share (repost) to help increase visibility!
Spread the Word / Share on Social Media

Helping us raise awareness of this research is a powerful form of support.

Even simply sharing this project on social media helps bring attention to our mission. If you’re unable to contribute financially, you can still support us by spreading the word online.

Support the Supporters of Biozipcode

Support the Supporters of Biozipcode

We need your support to develop a complete cure for diabetes and its complications. Funding is essential to bring this breakthrough treatment to the world through clinical trials.

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